A deranged female serial killer stalks seven young people whom phone a radio call-in show to discuss their darkest fears and a night-long game of cat-and-mouse is put into motion by the darkly sinister-looking murderess.

A successful Texas gynecologist finds himself amid a bevy of women and their problems – his wife’s breakdown, his daughter's fake marriage, his other daughter’s conspiracy theories, and his secretary’s crush. Craving time for himself, he finds solace in a kind outsider.