The Mothers-in-Law is an American sitcom starring Eve Arden and Kaye Ballard as two matriarchs who were friends and next-door neighbors whose children's elopement rendered them in-laws. The show aired on NBC from September 1967 to April 1969. Produced by Desi Arnaz, the series was created by Bob Carroll, Jr., and Madelyn Davis.

A government agent investigates the use of illegal amphetamines among long-haul truck drivers.