Tully Jr. and Earl live on their father's Nebraska ranch, proud and independent to a fault. While the shy, reclusive Earl spends his free time watching movies, the cockier Tully works his way through a succession of short-term affairs and an off-again, on-again relationship with April, a stripper in town. When their childhood friend Ella returns to town to start a veterinary practice, however, Tully falls for her — although the townsfolk have their doubts that he could ever commit to one woman.

A trio of interweaved transgressive tales, telling a bizarre stories of suburban patricide and a miraculous fight from justice, a mad sex experiment which unleashes a disfiguring plague, and the obsessive sexual relationship between two prison inmates.

The escapades of Huck Finn, Tom Sawyer, and the runaway slave, Jim, drifting down the Mississippi on a homemade raft, and their encounter with the Duke and his cohort, Dauphin.