The series initially starred veteran movie supporting actor Ward Bond as the wagon master, later replaced upon his death by John McIntire, and Robert Horton as the scout, subsequently replaced by lookalike Robert Fuller a year after Horton had decided to leave the series. The series was inspired by the 1950 film Wagon Master directed by John Ford and starring Ben Johnson, Harry Carey Jr. and Ward Bond, and harkens back to the early widescreen wagon train epic The Big Trail starring John Wayne and featuring Bond in his first major screen appearance playing a supporting role. Horton's buckskin outfit as the scout in the first season of the television series resembles Wayne's, who also played the wagon train's scout in the earlier film.

After a wild night, wealthy Michael Reston's adulterous wife Charleen comes home with her ripe young body barely concealed by a dress in rags; murder results. Top defense lawyer J.G. Blane, whose own marriage exists in name only, arrives in Desert View, Nevada to find the townsfolk and politically powerful Sheriff Hoak distinctly hostile to the Restons. In due course, Blane discovers he's been "taken for a ride," and that quiet desert communities can be deadly...