After returning to her home planet Pandora, infamous outlaw Lilith is given a dangerous mission and forms an alliance (and potential friendship) with other criminals, including former mercenary Roland, demolitionist Tiny Tina and her protector Krieg, insane scientist Tannis, and the wisecracking robot Claptrap. The mission: find and protect the missing (and important) daughter of a powerful man named Atlas. But things may not be as they seem, as the girl holds the key to great power that can change the fate of the universe.

Jack and Diane are forced to leave Indiana after discovering secrets about the death of Diane's mother. When their worst fears are confirmed by the chief of police, Jack and Diane create a "Hit List" and exact revenge on everyone involved.