After the original team developed a top-secret research laboratory to take the shattered ghosts to the next level. But when the discovery of an ancient artifact unleashes an evil force, both new and old must join forces to protect their homeland and save the world from the Second Ice Age... from the very thing that unleashes an unstoppable force from the depths of history. As chaos reigns and pure evil plunges the world into darkness, the Ghostbusters must step forward once again to save humanity from the brink of doom. With two generations of Ghostbusters fighting side by side, the stakes have never been higher. Will they be able to avert the inevitable before everything freezes?

Thirteen year old Sam Cleary suspects that his mysteriously reclusive neighbor Mr. Smith is actually the legendary vigilante Samaritan, who was reported dead 25 years ago. With crime on the rise and the city on the brink of chaos, Sam makes it his mission to coax his neighbor out of hiding to save the city from ruin.