Drug use in the city of Rome is at an all-time high. Children score from dealers in front of their schools, mules waltz straight through airport security, and Interpol's main man, Mike Hamilton (David Hemmings), is at his wits' end. Fed up to the back teeth with the local police force's incompetence, his only hope is to rely on one of his own men, Fabio (Fabio Testi), an officer so deep undercover that no-one but Hamilton knows who he really is. Even as Fabio gains the trust of cartel leader Gianni (John Loffredo), however, the dealers are edging ever closer to the truth, and when his cover is blown, the hunter becomes the hunted as Fabio finds himself alone in a desperate fight to survive.

Half-breed Keoma returns to his border hometown after service in the Civil War and finds it under the control of Caldwell, an ex-Confederate raider, and his vicious gang of thugs. To make matters worse, Keoma's three half-brothers have joined forces with Caldwell, and make it painfully clear that his return is an unwelcome one. Determined to break Caldwell and his brothers' grip on the town, Keoma partners with his father's former ranch hand to exact violent revenge.

Nico Palmieri is a police inspector who battles a criminal gang terrorizing a sleepy Italian town, extorting cash from the local merchants. With the threat of violence, no one dares to act, except for a restaurant owner who is forced by Palmieri to tell the truth.