A miracle pill intended to save the world causes unforeseen side-effects forcing the surviving gays and bible thumpers in a small Texas town to join forces or fall prey to the flesh craving mutants.

Paul Aufiero, a 35-year-old parking-garage attendant from Staten Island, is the self-described "world's biggest New York Giants fan". One night, Paul and his best friend Sal spot Giants star linebacker Quantrell Bishop at a gas station and decide to follow him. At a strip club Paul cautiously decides to approach him but the chance encounter brings Paul's world crashing down around him.