The adventures of a heroic and debonair stalwart mouse named Stuart Little with human qualities, who faces some comic misadventures while living with a human family as their child.

A maladjusted L.A. man named Henry Pinkle becomes suicidal when his favorite sitcom is cancelled. His plan to kill himself is thwarted by the mysterious Sam Bones, who promises to make Henry a star with the aid of a baby mask and hatchet.