Tully Jr. and Earl live on their father's Nebraska ranch, proud and independent to a fault. While the shy, reclusive Earl spends his free time watching movies, the cockier Tully works his way through a succession of short-term affairs and an off-again, on-again relationship with April, a stripper in town. When their childhood friend Ella returns to town to start a veterinary practice, however, Tully falls for her — although the townsfolk have their doubts that he could ever commit to one woman.

Paul Clark and his children are still heartbroken a year after the death of Jane, Paul's wife. When he unexpectedly falls in love with Mary, a former tennis-player, the couple decide to marry and live together. However, their lifestyles are completely different, and Mary is continuously reminded of the deceased Jane.