A group of young filmmakers, led by neophyte producer Alex Romero, venture out on a location scout in rural Pennsylvania. Deep into the back country, it quickly becomes apparent they have stumbled onto a family of werewolves and must now survive the night.

Passengers on their way to a tropical paradise crash at sea and find themselves on a deserted island. Desperate to survive the elements and infighting between survivors, they find that the island has more in store for them than they could ever imagine.