Based on the hepatitis C scandal that rocked Ireland in the mid-1990s. Two very different women discover that they have been infected with hepatitis C by a contaminated anti-D injection years before. Despite the devastating effects on the women and their families, they unite in a campaign group to take on the health authorities and expose the evasions and lies of the political and bureaucratic establishment.

Based on the novel by John McGahern and set in Ireland in the 1950s, the series tells the story of Moran and his children. Especially the girls find it difficult to get away from the influence of their despotic father and start living their own lives.