What To Do In Case of Fire? tells the humorous and touching story of six former creative anarchists who lived as house squatters in Berlin during its heyday in the 80s when Berlin was still an island in the middle of the former eastern Germany. At the end of the 80s they went their separate ways with the exception of Tim and Hotte, who have remained true to their ideals and continue to fight the issues they did as a group. In 2000, with Berlin as Germany's new capital, an event happens forcing the group out of existential reason to reunite and, ultimately, come to grips with the reason they separated 12 years ago.

Edward Kaminsky, an aging ad man, wants a golden parachute from his agency; he must first land the Opel auto contract. Rosa, a youth with wealthy parents, wants to establish herself as an artist. The clumsy and enthusiastic Viktor, not quite honest, wants work. When he wanders into Kaminsky's meeting with Opel and says something about irony, the Opel director wants him in on the campaign. Then he steals an idea from Rosa that the Opel director loves. Before Rosa discovers he's expropriated her idea, Rosa and Viktor become lovers. Father-son feelings materialize between Kaminsky and Viktor. Can the impulsive Viktor hold it together before Rosa learns the truth and flies away?