Kati and Steffi have been best friends since they were six. Now they're both 17 and enjoying the ups and downs of becoming adults together. While Kati's parents are religious and conservative, but argue constantly, Steffi comes from what appears to be a harmonious and liberal family. But the girls discover how quickly their attractive world can fall apart when, at a hip nightclub, they happen to see Steffi's father in the arms of another woman. Steffi is shocked, her trust in her small perfect world shaken to the core. She can only think of one thing: revenge.

What To Do In Case of Fire? tells the humorous and touching story of six former creative anarchists who lived as house squatters in Berlin during its heyday in the 80s when Berlin was still an island in the middle of the former eastern Germany. At the end of the 80s they went their separate ways with the exception of Tim and Hotte, who have remained true to their ideals and continue to fight the issues they did as a group. In 2000, with Berlin as Germany's new capital, an event happens forcing the group out of existential reason to reunite and, ultimately, come to grips with the reason they separated 12 years ago.