Doofenshmirtz's latest "-inator" accidentally turns the citizens of Danville into contagious mindless repulsive pharmacists that look like him who run rampant all over town. Agent P and the kids must work together to save Danville and avoid becoming mindless repulsive pharmacists themselves.

Phineas and Ferb turn the city of Danville into a giant thank you card for Santa Claus because they feel nobody ever thanks him for all the joy he brings to the world. Doofenshmirtz uses a device called the "Naughty-inator" to put the city of Danville on Santa's naughty list.