Chicagoan Frank Gallagher is the proud single dad of six smart, industrious, independent kids, who without him would be... perhaps better off. When Frank's not at the bar spending what little money they have, he's passed out on the floor. But the kids have found ways to grow up in spite of him. They may not be like any family you know, but they make no apologies for being exactly who they are.

After a small misunderstanding aboard an airplane escalates out of control, timid businessman Dave Buznik is ordered by the court to undergo anger management therapy at the hands of specialist Dr. Buddy Rydell. But when Buddy steps up his aggressive treatment by moving in, Dave goes from mild to wild as the unorthodox treatment wreaks havoc with his life.

The hilarity begins when professor Sherman Klump finds romance with fellow DNA specialist, Denise Gaines, and discovers a brilliant formula that reverses aging. But Sherman's thin and obnoxious alter ego, Buddy Love, wants out...and a big piece of the action. And when Buddy gets loose, things get seriously nutty.

Frank Drebin is persuaded out of retirement to go undercover in a state prison. There he has to find out what top terrorist, Rocco, has planned for when he escapes. Adding to his problems, Frank's wife, Jane, is desperate for a baby.