The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

During a sunny Sicilian summer Tanino has a sweet and tender story with Sally, a young American tourist. But when summer is over, Sally flies back to the States forgetting Tanino and her camera. He instead cannot forget the girl and he decides to go to the States with the excuse of bringing back her the camera and to see the dreamland of any Sicilian. Tanino will discover that dreams don't always match with reality...