Gru and Lucy and their girls — Margo, Edith and Agnes — welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad. Gru faces a new nemesis in Maxime Le Mal and his femme fatale girlfriend Valentina, and the family is forced to go on the run.

The Minions will try anything to help Agnes overcome her fear of the dark, even if it involves going into outer space.