In a neighborhood on the outskirts of Rome the crime, drugs and graffiti are pervasive. A large apartment complex seems to be a prison for the inhabitants. Marco returns to the hood after serving time in prison for dealing drugs but he's rejected and abandoned by his wife. His old friends still want him to deal cocaine for them. At first he's reluctant but it seems to be all he knows to do. Faustino, Massimo and Federico are delinquents who hang out together while doing drugs, petty crime, and looking for sex. Sonia is different from the rest because she studies and works all the time but even Sonia won't escape without being a victim. A tragic incident brings the main characters together and leaves behind a trail of fire, blood and violence.

Army colonel Gabriele Moresco and twelve of his soldiers occupy a hospital in Sicily, Italy, taking every patient and doctor as hostages and giving an ultimatum to the government: if they won't admit their role in hiding proof of the use of depleted uranium in the Balkan Wars and the subsequent countless cases of cancer among Italian soldiers in 56 hours, all the hostages will be killed. Negotiator Paolo Manfredi is called to save the hostages, not knowing that his wife and daughter are among them.