Television show host Brett and his laid-back science journalist girlfriend Tash despair that they will ever truly understand each other. On their first anniversary, under a full moon, a frustrated Tash declares her wish that they could swap lives. The next morning, Brett and Tash awaken to find Tash's wish has come true. Forced to confront the unfamiliar sensations of their "new" bodies, both must navigate strange new experiences with friends and co-workers.

Albert Einstein is the son of a Tasmanian apple farmer, who discovers the secret of splitting the beer atom to put the bubbles back into beer. When Albert travels to Sydney to patent his invention he meets beatuiful French scientist Marie Curie, as well as several unscrupulous types who try to take advantage of the naive genius and his invention.