A vengeful woman lures her half brother into a game that may leave her the sole heir to their abusive father's fortune.

A joint task force operation between the Drug Enforcement Administration and the U.S. Army has been formed to dismantle one of the largest drug cartels operating in South America. Multiple attempts to assault the cartel's mountainous compound have been thwarted by a Scorpion-attack helicopter piloted by a cartel leader, Eric Stoller (Bert Rhine). After having several aircraft shot down, most notably a pair of UH–60 Black Hawks and their AH–1 Cobra escorts, the army turns to the new AH–64 Apache attack helicopter, which can match its enemies' maneuverability and firepower.

By 2017, the global economy has collapsed and U.S. society has become a totalitarian police state, censoring all cultural activity. The government pacifies the populace by broadcasting a number of game shows in which convicted criminals fight for their lives, including the gladiator-style The Running Man, hosted by the ruthless Damon Killian, where “runners” attempt to evade “stalkers” and certain death for a chance to be pardoned and set free.