The story of several young people from around the world who represent the next stage in human evolution, possessing special powers, including the ability to teleport and communicate with each other telepathically. Together they work to defeat the forces of evil.

When her wild younger sister Ashley, who suffers from bipolar disorder and drug addiction, goes missing, Libba Phillips pours all her time and energy into finding Ashley and bringing her home. As the years go by, Libba refuses to give up hope, and, at the expense of her marriage and career, Libba finds her calling in life: creating a much-needed resource center for other families whose missing loved ones have fallen through the cracks.

16-year-old Lux was given up for adoption at birth but never adopted. When she is put back into the custody of her estranged-since-high-school birth parents, Cate and Baze, the three form an unlikely family.

Thanks to his police officer father's efforts, Shawn Spencer spent his childhood developing a keen eye for detail (and a lasting dislike of his dad). Years later, Shawn's frequent tips to the police lead to him being falsely accused of a crime he solved. Now, Shawn has no choice but to use his abilities to perpetuate his cover story: psychic crime-solving powers, all the while dragging his best friend, his dad, and the police along for the ride.

When they were boys, Sam and Dean Winchester lost their mother to a mysterious and demonic supernatural force. Subsequently, their father raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America ... and he taught them how to kill it. Now, the Winchester brothers crisscross the country in their '67 Chevy Impala, battling every kind of supernatural threat they encounter along the way.