Comanche Moon is a television miniseries that is an adaptation of the novel of the same name. It aired on CBS beginning Sunday, January 13, and continuing Tuesday, January 15, and Wednesday, January 16, 2008. It is a prequel to the original Lonesome Dove miniseries.

In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.

When rancher and single mother of two Maggie Gilkeson sees her teenage daughter, Lily, kidnapped by Apache rebels, she reluctantly accepts the help of her estranged father, Samuel, in tracking down the kidnappers. Along the way, the two must learn to reconcile the past and work together if they are going to have any hope of getting Lily back before she is taken over the border and forced to become a prostitute.

As America recovers from the Civil War, one man tries to put the pieces of his life back together but finds himself fighting a new battle on the frontier. Cable is an embittered Confederate soldier who returns from the war to reclaim his Arizona homestead from rebel pioneers who sympathize with the Union war effort.