A rancher fighting for his land and family stumbles upon an unfathomable mystery at the edge of Wyoming’s wilderness, forcing a confrontation with the Unknown in ways both intimate and cosmic in the untamable American West.

In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.

When he hears that the new female employee digs ambitious men who are the store employee of the month, a slacker gets his act together but finds himself in competition with his rival, an ambitious co-worker.

When rancher and single mother of two Maggie Gilkeson sees her teenage daughter, Lily, kidnapped by Apache rebels, she reluctantly accepts the help of her estranged father, Samuel, in tracking down the kidnappers. Along the way, the two must learn to reconcile the past and work together if they are going to have any hope of getting Lily back before she is taken over the border and forced to become a prostitute.