Gregório is a rustic and idealistic peasant who lives frustrated in the village of Rosillas. Arrogant and bold, he wants to recover the waters of the family's old dam, which were diverted by Colonel Igrejas, an Argentinean farmer who acts in collusion with the town's mayor to benefit the cultivation of his own vines. In the midst of all this, Gregório will have to face the contempt of the residents, the corruption and the socioeconomic power of the elite, leaving aside the love for his little son Olegário, the care for his elderly parents and the love of Paula, the teacher at the school who insists that he go live in the city. How does the one who stays on the land that everyone has decided to leave survives.

In 1995, several cargo containers are discovered high in the Bolivian Andes. Inside are potentially toxic chemicals, and local policeman Mariscal soon becomes charged with the task of smuggling the containers into neighboring Chile. He recommissions an old train to haul the toxic waste out of Bolivia, but encounters one mishap after another, beginning with the local townspeople who know what's inside, halting the train's path.

The legal and illegal status of immigrants and the discrimination endured by a segment whom are only looking to a better way of life.

In Bolivia, Butch Cassidy (now calling himself James Blackthorn) pines for one last sight of home, an adventure that aligns him with a young robber and makes the duo a target for gangs and lawmen alike.

As a director and his crew shoot a controversial film about Christopher Columbus in Cochabamba, Bolivia, local people rise up against plans to privatize the water supply.

After the Cuban Revolution, Che is at the height of his fame and power. Then he disappears, re-emerging incognito in Bolivia, where he organizes a small group of Cuban comrades and Bolivian recruits to start the great Latin American Revolution. Through this story, we come to understand how Che remains a symbol of idealism and heroism that lives in the hearts of people around the world.

Beggining in La Higuera, 1967 where the body of Ernesto Che Guevara is laid out and later secretly buried, Di buen dia a papa returns to this location over ten year intervals to focus on three generations of women affected by the event.