A womanizing sculptor seeks help from a psychiatrist to cure him of his obsession with women.

Two gamblers must leave New York City after one loses a lot of money. Doing what all gamblers in trouble would do, they hurry to the gambling capital Las Vegas to turn their luck around.

When an assassin's bullet confines him to a wheelchair for life ending his career as Chief of Detectives, Robert T. Ironside becomes a consultant to the police department. Detective Sergeant Ed Brown and policewoman Eve Whitfield join with him to crack varied and fascinating cases. Ex-con Mark Sanger is employed by the chief as home help but eventually becomes a fully fledged member of the team also. Officer Whitfield leaves after 4 years service, and is replaced by Officer Fran Belding.