A family man struggles to gain a sense of cultural identity while raising his kids in a predominantly white, upper-middle-class neighborhood.

A couple who seems to have it all pushes their sex life to the edge. The story gets intertwined when an old flame, betrayal, lust and deceit enter the picture.

In California, Maria has awful nightmares and visions of her sister who committed suicide one year ago. Her roommate Chris invites Maria to travel with her and her friends Tanya and Rose on vacation to her uncle's house in Saguaro, Arizona, to relax. When the group arrives in the house, they immediately go to a night-club to have fun and chase some local guys for sex; however, the evil El Charro is seeking Maria, killing her friends with his machete.

Follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital.