The story of The Blues traces the four main traditions of blues music: Form Blues, Blues, Urban Blues and Blues Electric. The blues has evolved and diversified, and filtered into a surprising variety of styles in contemporary music. In the blues the history of music was released. A look at the roots, origins and the subsequent influence of style the film explores the blues significant contribution to the development of jazz, rock and country and western music. Big Bill Broonzy, Robert Johnson, Lonnie Johnson, Blind Lemon Jefferson, Alexander Texas, and many more artists are featured through the film.

Jake Blues, just released from prison, puts his old band back together to save the Catholic home where he and his brother Elwood were raised.