Professor "Johnny Longbow" Salina, a man who really knows his stews, introduces Paul Carlson to the practical-joking Kathy Nolan. Paul and Kathy seem to hit it off rather well but, during a meteor storm, a meteorite fragment strikes Paul, burying itself deep in his skull, which has the unpleasant side-effect of causing Paul to mutate into a giant reptilian monster at night and go on murderous rampages. It turns out that this sort of thing has happened before, when Professor Salina rediscovers ancient Native American paintings detailing a similar event many centuries ago. Kathy, however, still loves Paul, and tries to save him.

Tara B. True is a flight attendant who makes a weekly swing through New York, Miami, and Los Angeles. In each city, she has a man: Edward, older and wealthy; Johnny, a beach bum with gambling debts; and, Davey, a rock musician on the cusp of success. Tara is a free spirit, faithful to each man in her own way, and so stunning that she dresses in a wig and ill-fitting uniform while she's working so men won't harass her constantly. The low-life whom Johnny is in debt to figures out a way to use Tara to help him execute a daring in-flight robbery. But will Tara stand by helplessly, or is superchick ready for action?