In Miami, Florida, biker gang leader Edward "Diablo" Santer is about to be executed for murder when he proclaims his innocence and vows revenge from the grave. When a mysterious biker comes to town during Spring Break festivities, leaving several teenagers electrocuted to death, some begin to suspect that Santer has made good on his promise.

A scientist at a Florida university inadvertently creates a "rage virus" while performing experiments intended to restore dead brain tissue in baboons. When a journalist for the college paper breaks into the campus lab, he's bitten by one of the infected baboons; the virus soon spreads to a trio of rapists and a valley girl, all of whom go on killing sprees.

Basket-case network news producer Jane Craig falls for new reporter Tom Grunnick, a pretty boy who represents the trend towards entertainment news she despises. Aaron Altman, a talented but plain correspondent, carries an unrequited torch for Jane. Sparks fly between the three as the network prepares for big changes, and both the news and Jane must decide between style and substance.

An Indian Vietnam veteran trains five street punks in the Everglades to fight vice in Miami.