Jessie deals with a bad breakup, by purchasing a sheet of acid to share with his friends back home in Missouri. He hopes this will erase the bad memory of his college girlfriend, delivering the heartbreaking news to him, during sex. Departing New Orleans, Jessie detours onto Route 61, seeking a change of routine from the monotony of the Interstate. Unexpectedly, his engine fails at a forgotten trailer park in Cleveland, Mississippi. Fearful he's about to be harmed by bikers, Jessie exchanges hits of L.S.D. for safe passage home. During the ebb and flow of the day, Jessie experiences the extraordinary in the pedestrian, whilst resurrecting the lives of many. Inspired by a true misadventure.

For three college guys, it’s senior year and the co-ed experience has left them high and dry. Their solution: A road trip to Mardi Gras, where beautiful babes are happy to lift their shirts and open containers are always welcome. But after dressing in drag, breaking into Carmen Electra’s hotel room, starring in a scandalous sex show and accidentally exploding a feces bomb in a swank hotel lobby, will the Mardi Gras magic kick in and their wildest fantasies come true?