When her grandson is kidnapped during the Tour de France, Madame Souza and her beloved pooch Bruno team up with the Belleville Sisters—an aged song-and-dance team from the days of Fred Astaire—to rescue him.

A young surgeon returns to her hometown to work in the local hospital. The relationship to her ex-lover, a well-known chief-surgeon, flames up again but not with happy consequences. The old friends become rivals in personal and professional fields.