40 years in the future, space captain Ryan Clark and the crew of the luxury space cruise ship Avenue 5 navigate disgruntled passengers and unexpected events after experiencing technical difficulties onboard.

Anthony Stowe is a dirty cop who is hooked on heroin—and everyone hates him. After a serious accident, he is placed into an induced coma, but emerges from it a better person who wants to put things right.

Catherine is a woman in her late twenties who is strongly devoted to her father, Robert, a brilliant and well-known mathematician whose grip on reality is beginning to slip away. As Robert descends into madness, Catherine begins to wonder if she may have inherited her father's mental illness along with his mathematical genius.

A raucous, angry exorcism of relationships and assorted fears, shadowed by the Big One: the plague of AIDS.