A look into American politics, revolving around former Senator Selina Meyer who finds being Vice President of the United States is nothing like she expected and everything everyone ever warned her about.

When a deadly airborne virus threatens to wipe out the northeastern United States, teacher Elliott Moore and his wife Alma flee from contaminated cities into the countryside in a fight to discover the truth. Is it terrorism, the accidental release of some toxic military bio weapon -- or something even more sinister?

When a presidential candidate dies unexpectedly in the middle of the campaign, the Democratic party unexpectedly picks a Washington, D.C. alderman as his replacement.

The vice president is dead, and as the president makes his choice for a replacement, a secret contest of wills is being waged by a formidable rival. When Senator Laine Hanson is nominated as the first woman in history to hold the office, hidden agendas explode into a battle for power.