In seeking her own redemption from the one man of whom she is most afraid, 10-year-old Cadi Forbes discovers a secret sin haunting her community of Welsh immigrants in 1850s Appalachia.

After the death of his wife, world-class neurosurgeon Dr. Andrew Brown leaves Manhattan and moves his family to the small town of Everwood, Colorado. There he becomes a small-town doctor and learns parenting on the fly as he raises his talented but resentful 15-year-old son Ephram and his 9-year-old daughter Delia.