Follow the lives of a group of students at what is possibly the world’s worst community college in the fictional locale of Greendale, Colorado.

In the late 21st century, a subculture of humans have emerged who have been modified genetically by a vampire-like disease, giving them enhanced speed, incredible stamina and acute intelligence. As they are set apart from "normal" and "healthy" humans, the world is pushed to the brink of worldwide civil war aimed at the destruction of the "diseased" population. In the middle of this crossed-fire is - an infected woman - Ultraviolet, who finds herself protecting a nine-year-old boy who has been marked for death by the human government as he is believed to be a threat to humans.

The everyday lives of office employees in the Scranton, Pennsylvania branch of the fictional Dunder Mifflin Paper Company.