Gunslinger Jonah Hex is appointed by President Ulysses Grant to track down terrorist Quentin Turnbull, a former Confederate officer determined on unleashing hell on earth. Jonah not only secures freedom by accepting this task, he also gets revenge on the man who slayed his wife and child.

Mikey and Rose are professional assassins. They are also lovers, and once upon a time Rose also knew Mikey's father. During an elaborate hit job for a malicious gangster, Rose fails to kill the main target, the gangster's pregnant girlfriend. Instead, she delivers her baby and convinces Mikey to help her protect them both. As Rose weakens from cancer, Mikey becomes breadwinner for this unusual family. But tranquility will not last.