A case involving drug lords and murder in South Florida takes a personal turn for undercover detectives Sonny Crockett and Ricardo Tubbs. Unorthodox Crockett gets involved romantically with the Chinese-Cuban wife of a trafficker of arms and drugs, while Tubbs deals with an assault on those he loves.

Residents of an adult community in Florida turn to one another for support and companionship after the deaths of their spouses. Lois has a rejuvenating affair with a younger man while acting as best friend to recently widowed Marilyn. Jack buddies up with Harry for a crash course in solo survival skills and deals with single gal Sandy's romantic overtures.

In a prison for the criminally insane, deranged anthropologist Ethan Powell is set to be examined by a bright young psychiatrist, Theo Caulder. Driven by ambition and a hunger for the truth, Caulder will eventually risk everything—even put his very life on the line—in a harrowing attempt to understand the bizarre actions of this madman.

Gabriela, a Colombian immigrant, is obsessed with understanding violent crime. The current string of murders by "The Blue Blood Killer" of affluent Miami socialites provides her with fodder for her scrapbook of death. She lands a job with a post-murder cleaning service and during a Blue-Blood clean-up job, discovers evidence that police have overlooked.

In the early 21st century, mankind has colonized the oceans. The United Earth Oceans Organization enlists Captain Nathan Bridger and the submarine seaQuest DSV to keep the peace and explore the last frontier on Earth.