A long love story, seen through the memories of one young couple. The journey through the years of two individuals, united, divided, happy, unhappy, deeply in love, or in love with others, in a single stream of emotions and shades of feeling. Over the course of the film, he learns that love can indeed last, while she learns to live with nostalgia.

Professor Biondi is a depressed scientist. After his wife's death, he lives isolated from the world in the Nevada desert, near Area 51. He supposedly works on a top-secret project for the US government, but in actuality, he spends his days on the couch, listening to the sound of the Universe. His only contact with the outside world is Stella, who organizes alien-themed weddings for tourists on the prowl for extra-terrestrials. One day the Professor receives a message from Naples: his dying brother is entrusting him with his two children, so that they may live with him in America.

In Tuscany to promote his latest book, a middle-aged English writer meets a French woman who leads him to the village of Lucignano.

Nanni Moretti takes another look at the ebbs and flows of life in April 1996, as he becomes a father for the first time and seems unable to focus on his documentary about the upcoming national elections.