Six years after the events of The X-Files series finale, former FBI agent Doctor Dana Scully is now a staff physician at Our Lady of Sorrows, a Catholic hospital, and treating a boy named Christian who has Sandhoff disease, a terminal brain condition. FBI agent Drummy arrives to ask Scully’s help in locating Fox Mulder, the fugitive former head of the X-Files division, and says they will call off its manhunt for him if he will help investigate the disappearances of several women, including young FBI agent Monica Banan. Mulder and Scully are called back to duty by the FBI when a former priest claims to be receiving psychic visions pertaining to a kidnapped agent.

The exploits of FBI Special Agents Fox Mulder and Dana Scully who investigate X-Files: marginalized, unsolved cases involving paranormal phenomena. Mulder believes in the existence of aliens and the paranormal while Scully, a skeptic, is assigned to make scientific analyses of Mulder's discoveries that debunk Mulder's work and thus return him to mainstream cases.

A homicide detective finds himself being stalked by a killer responsible for a series of mob style executions.

Three soldiers of fortune get together for one last job. However, one of them falls for a drug-addicted hooker, and when her crazed pimp gets involved, complications ensue.