Inspired by the book The Lives of the Most Excellent Painters, Sculptors, and Architects by painter Giorgio Vasari, this historical soap opera, in which betrayals, kidnappings, murders and police investigations are interwoven, relates the discovery by the Italians of the secret of Flemish painting around 1470.

Font-aux-cabres is the name of an Andalusian village, benefiting the Commander of the Order of Calatrava, who supports Juana Beltraneja, the pretender to the throne of Castile, against the Catholic Monarchs. The Commander's tyranny is felt throughout the country, subjecting village women and girls to his whims by threat or violence. Laurencia, who dares to refuse him, is kidnapped on her wedding day, and her fiancé Frondoso is imprisoned.