Cocky young attorney Michael Gray finds himself framed for murder when an inmate he is defending violently kills himself during their interview at South River State Penitentiary. Now locked in the same nightmarish Cell 213 where his client died, he soon realizes that unnatural forces are behind a string of inmate suicides, making matters of guilt and innocence not as cut and dry as they seem.

A couple and their six-year-old son move into an old Connecticut house where the boy soon becomes distraught with thoughts of monsters dwelling in the attic. When their friends and guests abruptly go missing or die mysteriously, it becomes a race against time as the family's lives are in peril.

Now serving a life sentence for murder, James "Animal" Allen returns to fighting for cash in order to help his troubled son on the outside. However, with his newfound fame as a fighter, Animal uncovers a jailhouse conspiracy that threatens to cause racial tensions to explode.

As the city is locked down under quarantine, Alice finds out that the people that died from the previous incident at the Umbrella Corporation have turned into zombies. She then joins a small band of elite soldiers, who are enlisted to rescue the missing daughter of the creator of the mutating T-virus. Once lack of luck and resources happen, they begin to wage an exhilarating battle to survive and escape before the Umbrella Corporation erases its experiment from the face of the earth.