An emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room.

A day in the life of a Chicago cab driver is examined as he picks up fares from the good and bad parts of the city and emotionally connects to many of his passengers.

Emma is an attractive girl in her 20s who has been blind for 20 years. A new type of eye operation partially restores her sight, but she is having problems: sometimes she doesn't "remember" what she's seen until later. One night she is awakened by a commotion upstairs. Peering out of her door, she sees a shadowy figure descending the stairs. Convinced that her neighbour has been murdered she approaches the police, only to find that she is unsure if it was just her new eyes playing tricks on her.

Rudy grew up in a steel mill town where most people ended up working, but wanted to play football at Notre Dame instead. There were only a couple of problems. His grades were a little low, his athletic skills were poor, and he was only half the size of the other players. But he had the drive and the spirit of 5 people and has set his sights upon joining the team.

Honest and straightforward small-town Shirlee Kenyon chucks her boyfriend and heads for Chicago. Accidentally having to host a radio problem phone-in show, it is clear she is a natural and is hired on the spot. But the station insists she call herself Doctor, and as her popularity grows a local reporter starts digging for the truth. Problem is, the more he is around her the more he fancies her.

Detective Tony Church is forced to retire and become a store rent-a-cop when his drug sting operation comes to a tragic end by a masked killer. He joins forces with a prostitute, the only one able to identify the killer, to bring him to justice.

When a Chicago teen is arrested for drug possession, the ensuing investigation reveals that he has had sexual contact with an older man. Discovering his sexual encounter, other students start shunning him and call for his expulsion from school. His father as his conservative blue-collar dad also rejects him, while his mother does try to offer support.

Two doctors, a father and son, conceal their alcohol and drug problems in this potent look at the abuse of those substances that exist in the medical profession.

A bartender struggling for years as an unpublished writer helps a combat veteran face his fears over publishing a short story about his time in Iraq.