Autumn in New York follows the sexual exploits of Will Keane - New York restaurateur, infamous verging-on-50 playboy, master of the no-commitment seduction - until he runs into an unexpected dead end when he meets Charlotte Fielding. Charlotte is half Will's age and twice his match, a 21 year-old free spirit yearning to get out and taste the excitement of adult life.

Veronica suspects that her husband, an attractive teacher, is unfaithful to her. The worries don't even let her sleep, so she decides to go to a sleep therapy to overcome her pathology.

Desperate to escape his mind-numbing routine, uptown Manhattan office worker Paul Hackett ventures downtown for a hookup with a mystery woman.