Expectant parents become prime suspects in the disappearance of a pregnant woman who was last seen at their garage sale. Model citizen David Rose runs a garden center and is a devoted house-father. Like his wife Ivy, who suffered two stillbirths, their new neighbor Melinda is near to giving birth. Just after David showed her around in the Rose home, Melinda goes missing. Although no corpse is found, just circumstantial evidence more likely to be planted then stupidly left behind, police detective Blanchard treats David as his sole suspect, soon arrested, even after nosy neighbor Bindel is knocked down while David is in jail. School buddy Theo does his best to counsel the couple, yet Ivy doubts her husband's innocence just because of indications he may have had an affair with Melinda since high-school, and starts snooping with her best friend Jody. The worst crime is still being hatched.

Would be filmmakers, Nick and Vince, dream of making it big and getting out of Nowheresville. Their goal is to make the next indie blockbuster of Blair Witch proportions and they have just the idea to take them to the top: a documentary about their hometown hero Scott Speedman. As Nick and Vince scour the city to document Scott Speedman stories, they encounter prolific producer Dietrich Baum, who agrees to help them if they can get the "actual Scott Speedman" in their movie. Nick and Vince seem destined to succeed. The only thing in their way, is reality.

Acting on impulse, Claire Dennison (Willa Ford), enjoys a brief fling with a sexy stranger (a dead ringer for her husband), only to realize that the object of her desire is a crazed, manipulative, and tenacious psychopath.

Thanks to his police officer father's efforts, Shawn Spencer spent his childhood developing a keen eye for detail (and a lasting dislike of his dad). Years later, Shawn's frequent tips to the police lead to him being falsely accused of a crime he solved. Now, Shawn has no choice but to use his abilities to perpetuate his cover story: psychic crime-solving powers, all the while dragging his best friend, his dad, and the police along for the ride.

4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.