At a national park in Kenya, English game warden George Adamson and his wife, Joy, care for three orphaned lion cubs. After the two larger lions are shipped off to a zoo in the Netherlands, the smallest of the three, Elsa, stays with the couple. When Elsa is blamed for causing an elephant stampede in the nearby village, head warden John Kendall demands the young lion either be trained to survive in the wilds of the Serengeti or be sent to a zoo.

When embittered safari guide David Kirby accepts a fateful commission to lead a hunting trip for wealthy and ruthless American Mitchell Gifford, tragedy soon intervenes and the big game hunt becomes a man hunt.