A fresh and funny take on modern friendship and what one urban family will do to stay friends after the perfect couple who brought them all together break up on their wedding day. The failed wedding forces them all to question their life choices. Then there are Alex and Dave themselves, who strike a truce and must learn to live with the changes their breakup has brought.

A psychotic man opens fire in a diner, murdering numerous people before killing himself. The survivors struggle in different ways following this horrendous event: a doctor doubts his own instincts and elects to use an experimental medical procedure on his wife, while a gambler believes he's on a lucky streak. A waitress begins engaging in promiscuous sex, and a young girl whose father is among the dead gains unexpected fame.

Tom Hanks is the host of this show with a comic approach to raise awareness concerning the environment.