Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.

Brand-new interviews with director Iain Softley, cast members Fisher Stevens, Matthew Lillard and Penn Jillette, costume designer Roger Burton, visual effects artist Peter Chiang, and more!