Letter to Loretta is an American anthology drama series telecast on NBC from September 1953 to June 1961 for a total of 165 episodes. The filmed show was hosted by Loretta Young who also played the lead in various episodes. Letter to Loretta was sponsored by Procter & Gamble from 1953 through 1960. The final season's sponsor was Warner-Lambert's Listerine.

This semi-film within a film opens in the office of producer George Jessel, who never saw a camera he couldn't get in front of, who is holding a story conference to determine the screen treatment for the life of Eva Tanguay, and Jessel is unhappy with what the writers present him.He tells them to look up Eddie McCoy, Eva's one-time partner, for the real inside story on the lusty and vital Eva. Eddie's version is that he discovered her working as a waitress in an Indianapolis restaurant in 1912, wherein singer Larry Woods and his partner Charles Bennett get into a fight over her and both land in the hospital, and McCoy convinces the manager to put Eva on as a single to fill their spot. She flopped, but McCoy arranges for Bennett to be her accompanist, and she went out of his life. The writers look up Bennett, now head of a music publishing company, who says McCoy's story is phony, and it was Flo Zigfeld who discovered Eva for his Follies.

A college basketball star collaborrates with organized crime and becomes involved in 'point shaving.' A sportswriter tries to get him back on the right track.

A woman wakes up in the middle of the night on board a train, but she can't remember how she got there. Danger and suspense ensue.

Charley Davis, against the wishes of his mother, becomes a boxer. As he becomes more successful the fighter becomes surrounded by shady characters, including an unethical promoter named Roberts, who tempt the man with a number of vices. Charley finds himself faced with increasingly difficult choices.

In the wake of Pearl Harbor, a young lieutenant leaves his expectant wife to volunteer for a secret bombing mission which will take the war to the Japanese homeland.

A idealistic shipyard worker interests a beautiful Hollywood star in staging a musical tribute to the war industry, but they disagree on some important issues.

1940. Sixteen year old Phillip is one of a number of amateur radio operators across the US, doing it purely as a fun hobby. He is informed by Bill Beck of the Radio and Intelligence Division (RID) of the Federal Communications Commission (FCC) that amateur international radio communication is now banned due to spying a result of the war in Europe. Beck, on behalf of the RID, asks Phillip, however, to continue to monitor the airwaves for suspicious activity.

Hat check man Louis Blore is in love with nightclub star May Daly. May, however, is in love with a poor dancer but wants to marry for money. When Louis wins the Irish Sweepstakes, he asks May to marry him and she accepts even though she doesn't love him. Soon after, Louis has an accident and gets knocked on the head, where he dreams that he's King Louis XV pursuing the infamous Madame Du Barry.