Thanks to a Japanese scientist's invention of synthetic, blood vampires have progressed from legendary monsters to fellow citizens overnight. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin." Religious leaders, government officials, and vampire fundamentalists around the world have chosen their sides, but in the small Louisiana town of Bon Temps, the jury is still out.

Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.

A cunning psychopath with more than an axe to grind murders the kindly Mailman in a small, placid suburban town. Darius Foxx scarred for life as a young boy by seeing his parents brutally murdered, comes back to town as the new Mailman to torment his younger brother, Daniel, and Daniel's adopted family.

In this direct-to-video sequel, Gabriel returns to try to destroy the human race he despises so much, with the help of a suicidal teen and the opposition of the angel Daniel.